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Mesenchymal stem cell culture on poly(N-isopropylacrylamide) hydrogel with repeated thermo-stimulation

Int. J. Mol. Sci., 19, 1253-1263 (2018).

Aya M. Akimoto*, Erika Hasuike Niitsu (co-first), Kenichi Nagase, Teruo Okano, Hideko Kanazawa, and Ryo Yoshida*



We designed thermoresponsive hydrogels for cell culture and human bone marrow‐derived mesenchymal stem cells (hbmMSCs) were cultured on them. Repeated changes in the swelling ratio of the PNIPAAm gel affected the shape of the hbmMSCs. With respect to both cytocompatibility and reversibility of changes in mechanical properties, the PNIPAAm gel system could be potentially useful for the analysis of cell mechanobiology.

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